Botox®, Dysport®, Xeomin®, Jeuveau®, and Daxxify® are all FDA-approved botulinum toxin type A neuromodulators, they relax the muscles that create expression lines. But they differ in molecular formulation, onset speed, spread characteristics, duration, and unit dosing in ways that make some brands better suited to specific areas and patient profiles.
Daxxify® is the most significant advancement in this category in decades.Its peptide stabilizer binds faster to nerve receptors and produces results lasting 6–9 months, most patients need only two treatments per year rather than three or four. It is vegan, contains no human or animal-derived proteins, and has the fastest onset of all five brands.
Arbour Longevity selects the right brand for your specific treatment area, anatomy, and lifestyle, something a practice with only one or two brands on the shelf cannot offer. The best outcome comes from matching product to patient, not defaulting to whatever is most familiar.
Botox®: The Standard
Most studied · Predictable · Best for precision areas · 3–4 months
Daxxify®: Longest Lasting
6–9 months · Peptide-based · Vegan · Fastest onset · 2 treatments/year
Dysport®: Fastest & Broadest
2–3 day onset · Good for larger areas (forehead) · 3–4 months
Xeomin®: Pure Form
No accessory proteins · Preferred for long-term use · 3–4 months
Jeuveau®: Aesthetics-Only
Designed exclusively for cosmetic use · Fast onset 2–3 days
Allergan · Most Popular
onabotulinumtoxinA
The gold standard. Decades of safety data.
The most studied, most widely used neuromodulator in the world. Predictable results, controlled spread, and a 20+ year clinical track record. The default choice for precision areas and first-time patients.
Onset
4–7 days
Duration
3–4 months
Visits/year
3–4
Revance · Longest Lasting
daxibotulinumtoxinA-lanm
6–9 months. The only neuromodulator that lasts this long.
Daxxify® uses a peptide stabilizer that binds faster and holds longer, producing results lasting 6–9 months compared to 3–4 months for other brands. Two treatments per year. Vegan. No human or animal proteins. Fastest onset of all five brands.
Onset
1–2 days
Duration
6–9 months
Visits/year
2
Galderma · Fastest Spread
abobotulinumtoxinA
Fast onset. Broader diffusion. Ideal for large areas.
Dysport® diffuses more broadly than Botox®, making it well-suited for the forehead where broader coverage is desirable. Onset as fast as 2–3 days. Note: requires roughly 2.5× the units of Botox® for equivalent effect; compare total area cost, not per-unit price.
Onset
2–3 days
Duration
3–4 months
Visits/year
~2.5× vs Botox®
Merz · Pure Formula
incobotulinumtoxinA
Stripped of accessory proteins. Preferred for long-term treatment.
Xeomin® is a “naked” neurotoxin, processed to remove accessory proteins while preserving only the active toxin. Some clinicians prefer it for long-term patients where reducing potential antibody development is a consideration. Unit dosing equivalent to Botox®.
Onset
3–5 days
Duration
3–4 months
Visits/year
1:1 vs Botox®
Evolus · Aesthetics-Only
prabotulinumtoxinA-xvfs
Designed purely for cosmetic use. Fast onset.
Jeuveau® was developed exclusively for aesthetic use, not repurposed from a medical formulation. Fast 2–3 day onset, unit dosing equivalent to Botox®, and often the most accessible price point for patients maintaining regular treatments. Particularly popular with younger preventive-use patients.
Onset
2–3 days
Duration
3–4 months
Visits/year
1:1 vs Botox®
Note on Dysport®: Dysport® has a different unit conversion ratio, your clinician explains the comparison at your appointment. Your clinician provides a direct comparison at consultation.
The vertical lines between the brows, the “11s,” are the most commonly treated area and the primary FDA-approved indication for all five brands. Creates a more relaxed, approachable expression without looking frozen when done well.
The lateral periorbital lines that appear with smiling and squinting, one of the areas where technique matters most. The goal is softening without eliminating the expression entirely. Precise placement preserves natural movement.
Strategic placement of small amounts laterally at the brow depressors (orbicularis) elevates the brow tail, opening the lateral eye area and producing a subtle lift without surgery. Can be combined with PDO brow threads for a more significant result.
The diagonal lines across the nasal bridge that appear with facial expressions, most visible when smiling or scrunching. Often overlooked but significant for patients who want comprehensive upper face smoothing.
Small doses in the orbicularis oris relax the upper lip muscle, causing it to subtly “flip” outward, creating the appearance of a fuller upper lip without adding volume. An elegant alternative to lip filler for patients seeking subtle definition enhancement.
The “peau d’orange” or cobblestone texture of the chin produced by mentalis muscle hyperactivity responds well to small neuromodulator doses, producing a smoother, more refined chin surface. Often combined with chin filler for comprehensive lower face improvement.
Botox® injected into the masseter muscle achieves two outcomes simultaneously, slimming the lower face by reducing masseter hypertrophy, and relieving the jaw tension, headaches, and dental wear associated with bruxism. One of the highest-demand treatments among Arbour Longevity's patients. Results take 4–6 weeks as muscle atrophy develops.
Platysmal bands, the vertical cords that appear in the neck with aging and muscle use, respond well to careful neuromodulator placement. The “Nefertiti lift” technique extends treatment to the lower face and jawline simultaneously, producing a subtle neck and jaw lift effect. Often combined with PDO thread neck treatment.
Excessive sweating of the underarms, palms, or soles is one of the most clinically significant medical applications of neuromodulators. Botox® blocks the nerve signals to sweat glands, producing dramatic reduction in sweating lasting 6–12 months in most patients. A life-changing treatment for patients who have struggled with hyperhidrosis.
Jaw clenching, teeth grinding, and temporomandibular joint pain driven by masseter and temporalis hyperactivity respond dramatically to neuromodulator treatment. Arbour Longevity approaches this as a clinical protocol: assessing jaw anatomy, symptom severity, and the interaction with dental management.
Excessive gingival display, where the gum line is visible when smiling, can be dramatically reduced by precise injection of the levator labii superioris alaeque nasi muscle. Small amounts, precise placement, significant aesthetic impact for appropriate candidates.
The depressor anguli oris (DAO) pulls the corners of the mouth downward, producing a resting expression that reads as unhappy or disapproving. Relaxing this muscle lifts the mouth corners into a more neutral position, significantly improving resting expression without the frozen look of over-treating larger areas.
Your Arbour Longevity Neuromodulator Session
Post-treatment: Avoid lying down for 4 hours. No vigorous exercise for 24 hours. No facial massage or pressure on treated areas for 24 hours. Mild redness or swelling at injection sites resolves within hours. Touch-up appointments are available at 2 weeks if any area needs adjustment, always at no additional charge for same-session underdosing.
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Frequently Asked Questions
Neuromodulator treatments at Arbour Longevity vary based on the areas treated, the brand chosen, and the number of units your anatomy requires. Treatments typically start from a few hundred dollars for a single targeted area and scale with the scope of the plan. Daxxify®, which lasts 6–9 months, can make the annual investment comparable to or less than shorter-duration brands despite a higher per-session cost. Your clinician provides an exact cost at your appointment before treatment begins.
Daxxify® uses a peptide-based stabilizer, no human or animal proteins, that binds faster to nerve receptors and produces results lasting 6–9 months, compared to 3–4 months for Botox®. Most Daxxify® patients need only 2 treatments per year. It also has the fastest onset of all five brands, visible results as early as 24–48 hours. It uses approximately twice the units of Botox®, but the per-treatment cost is often comparable or lower annually due to fewer appointments needed.
It depends on your treatment area, lifestyle, and goals. Botox® for precision and familiarity. Daxxify® for maximum duration and fewer appointments, ideal for busy schedules. Dysport® for the forehead where broader spread is beneficial. Xeomin® for long-term patients preferring a pure-form product. Jeuveau® for an aesthetics-only formula at an accessible price point. Your Arbour Longevity clinician discusses all five at consultation and makes a specific recommendation based on your facial anatomy and goals.
Yes, one of the most clinically significant applications of neuromodulators. Botox® relaxes the masseter muscle responsible for jaw clenching and bruxism, reducing jaw pain, headaches, and dental wear while simultaneously slimming the lower face. Typical protocol: 25–50 units per side. Results develop over 4–6 weeks as the muscle gradually reduces in hyperactivity, lasting 4–6 months.
Standard brands (Botox®, Xeomin®, Jeuveau®): 3–4 months for most patients. Dysport®: 3–4 months. Daxxify®: 6–9 months, the longest of any available brand. Duration varies with individual metabolism, treatment area, and unit dosage. Regular maintenance at appropriate intervals preserves results and can extend duration over time.
"I switched to Daxxify® after years of Botox® and the difference in duration is exactly what was promised. I went from 4 appointments a year to 2. The results look identical, just last twice as long."
"The masseter treatment changed my life. I'd had jaw pain and grinding for years. Six weeks after treatment, no more morning headaches, no more jaw soreness. The jawline slimming was a bonus I didn't expect to notice as much as I did."
"I appreciate that Arbour Longevity actually explains the difference between the brands rather than just defaulting to whatever. My clinician recommended Jeuveau® for my first treatment and the result was exactly what I wanted, natural, not frozen."
Botox & Neuromodulators · Ann Arbor, Dexter
Book your Arbour Longevity neuromodulator appointment. Your clinician assesses your facial anatomy, recommends the right brand and unit count, and delivers the result, natural, precise, and exactly as discussed.
Regenerative medicine and aesthetic arts: where science meets the artistry of transformation.
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