The Biology of Fat Loss Finally Addressed.
- Tirzepatide, FDA approved
- GLP-1 + GIP Dual Agonist
- Clinician-Prescribed & Supervised
- Retatrutide, investigational triple agonist
Every Medication. Every Regulatory Status. Fully Disclosed.
GLP-1 / GIP Dual Agonist · Gold Standard
Tirzepatide
Mounjaro® (T2D) · Zepbound® (Obesity) · Compounded versions available
Tirzepatide is the most clinically studied and FDA-approved GLP-1/GIP dual agonist for weight loss. Its simultaneous activation of both GLP-1 and GIP receptors produces appetite reduction, improved insulin sensitivity, slowed gastric emptying, and metabolic effects that single GLP-1 agonists cannot fully replicate. Phase 3 clinical trials demonstrated highly significant body weight reduction outcomes across diverse patient populations. It is the first-line medication in Arbour Longevity's weight loss program for eligible patients.
- FDA-approved for type 2 diabetes (Mounjaro®) and chronic weight management (Zepbound®). Compounded tirzepatide prescribed under applicable 503A/503B regulations. Brand-name formulations also available. Contraindications, including personal/family history of medullary thyroid carcinoma and MEN 2, reviewed at consultation.
Typical Administration
Subcutaneous injection · Weekly · Titrated from starting dose under clinician supervision · Patient self-administered
GLP-1 / GIP / Glucagon Triple Agonist · Investigational
Retatrutide
Triple Agonist · Investigational Compound · Phase 3 Clinical Trials
Retatrutide adds glucagon receptor agonism to the dual GLP-1/GIP mechanism, potentially increasing energy expenditure beyond what appetite suppression alone achieves. Phase 2 trial data demonstrated body weight reduction outcomes that represent some of the highest figures recorded in pharmaceutical trials to date. It is currently in Phase 3 trials. This compound has not received FDA approval. It is prescribed as an investigational compound with comprehensive informed consent.
- ⚠ INVESTIGATIONAL, not FDA approved. Phase 3 clinical trials ongoing. Prescribed at Arbour Longevity as an investigational compound following comprehensive evaluation, full regulatory and evidence disclosure, risk discussion, and written informed consent. Compounding availability is subject to current regulations.
Typical Administration
Subcutaneous injection · Weekly · Clinician-supervised titration required · Patient self-administered
Biguanide · Insulin Sensitizer · Metabolic Support
Metformin
Glucophage® · Established metabolic medication
Metformin is one of the most studied medications in metabolic medicine, improving insulin sensitivity, reducing hepatic glucose production, and supporting metabolic efficiency. In weight loss programs it may be used adjunctively to address insulin resistance that limits fat loss, particularly in patients with metabolic syndrome, pre-diabetes, or PCOS. Off-label use in weight management is disclosed at consultation.
Typical Administration
Oral tablet · Daily or twice daily · Titrated to minimize GI side effects
Anticonvulsant · Appetite Modulation Adjunct
Topiramate
Topamax® · Weight Loss Adjunct When Indicated
Topiramate is FDA-approved for epilepsy and migraine prophylaxis and is used off-label as an appetite modulation adjunct in weight management programs. It may enhance the appetite-reducing effects of GLP-1 therapy in select patients. It is used at Arbour Longevity only when clinically indicated based on individual patient profile, not as a routine component of every program. Full off-label disclosure and risk discussion occur at consultation.
Typical Administration
Oral tablet · Low-dose · Used when clinically indicated · Titrated under supervision
B12 Injections · Metabolic IV · Tesamorelin
B12 Injections
Methylcobalamin injections support cellular energy metabolism and neurological function, addressing the fatigue that often accompanies caloric restriction and metabolic change. Available weekly or bi-weekly during your program.
Metabolic IV Therapy
Our Metabolic Reset IV delivers the B-Complex, Alpha Lipoic Acid, L-Carnitine, and Magnesium most depleted during active weight loss, supporting metabolic function, energy, and helping prevent the micronutrient deficiencies that slow progress.
Tesamorelin
A GHRH analogue FDA-approved for HIV-associated lipodystrophy, used off-label for visceral adipose tissue reduction. May specifically target metabolically active abdominal fat when GLP-1 therapy alone is insufficient. Full off-label disclosure at consultation.
GLP-1 / GIP Therapy · Ann Arbor
The Fat Loss Results You Stopped Believing Were Possible.
Schedule a GLP-1 consultation at Arbour Longevity. We review your metabolic history, current health status, and prescribe the protocol that is clinically appropriate, with complete transparency about every medication, its evidence, and its regulatory status.
Regenerative medicine and aesthetic arts: where science meets the artistry of transformation.
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