PT-141 & Kisspeptin

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PT-141 · Kisspeptin · Neurological Desire Support · Men & Women

When Desire Needs More Than Blood Flow.

Every other sexual wellness treatment in medicine, including PDE5 inhibitors, PRP, and LiSWT, addresses the vascular and structural dimensions of sexual function. None of them address the neurological dimension: desire itself. PT-141 (bremelanotide) is the only approved pharmaceutical that activates sexual desire at the level of the central nervous system. Kisspeptin stimulates the upstream hormonal axis that governs endogenous testosterone and LH production. Together, they address the dimension that purely vascular treatments miss.

PT-141

Bremelanotide · Brand Name: Vyleesi®

Mechanism: Melanocortin receptor agonist (MC3R, MC4R). Acts centrally on the CNS, not on blood flow. FDA-approved for HSDD in premenopausal women. Off-label use in men for low libido and ED.

Unlike Viagra or Cialis, which work on blood vessels, PT-141 works on your brain. It activates melanocortin receptors in the hypothalamus that govern the neurological pathway for sexual arousal and desire. It does not require physical stimulation to initiate its effect. It initiates the desire response itself.

Effects: onset 30–45 minutes post-subcutaneous injection. Duration: up to 72 hours. Effective for both men and women. Particularly valuable for patients with primarily psychological or neurological libido dysfunction, where vascular treatments produce limited results.

Arbour Longevity offers PT-141 as compounded bremelanotide, significantly more cost-effective than brand-name Vyleesi. Pricing is discussed at consultation. No telehealth markup. No subscription required.

Most common side effect: nausea (40%), manageable with antiemetics if needed. Contraindicated in uncontrolled hypertension and cardiovascular disease. All contraindications reviewed at consultation.

Off-label disclosure: PT-141 is FDA-approved for HSDD in premenopausal women. Its use in men and postmenopausal women is off-label. This use is clinically assessed and fully disclosed at consultation.

Kisspeptin

Kisspeptin-10 · HPG Axis Activator

Mechanism: Neuropeptide activating kisspeptin receptors in the hypothalamus · stimulates GnRH pulse release · drives LH/FSH · amplifies endogenous testosterone production.

Kisspeptin addresses sexual function at the most upstream point possible: the hypothalamic-pituitary-gonadal axis. By stimulating pulsatile GnRH release, Kisspeptin amplifies the body's own testosterone production, without the HPG-axis suppression that exogenous testosterone causes. This makes it particularly valuable for younger patients, patients who want to preserve fertility, or those who want to improve endogenous function before committing to TRT.

For women, Kisspeptin modulates the hormonal axis that governs libido and arousal, independent of estrogen. It also supports the restoration of HPG function in women with hypothalamic amenorrhea or post-OCP hormonal disruption. The Kisspeptin + PT-141 stack addresses both the upstream hormonal dimension (Kisspeptin) and the central neurological desire pathway (PT-141), the most comprehensive non-pharmaceutical approach to libido support available.

Kisspeptin + PT-141 stack pricing discussed at consultation, consistent with Arbour Longevity's standard peptide protocol model.

Why the Combination is More Powerful Than Either Alone

Kisspeptin Alone

Amplifies endogenous testosterone. Addresses the hormonal axis. Produces gradual, sustained improvement in libido and energy over weeks. No acute effect.

PT-141 Alone

Activates neurological desire pathway acutely. Rapid onset (30–45 min). Effects last up to 72 hours. No chronic hormonal foundation effect.

Combined Stack

Kisspeptin builds the hormonal foundation. PT-141 activates desire acutely when needed. Chronic improvement + on-demand activation. The most complete libido program available without pharmaceutical intervention.

PT-141 · Kisspeptin · Ann Arbor

Desire Isn't Just
Vascular. Treat the
Whole System.

PT-141 and Kisspeptin are assessed at consultation alongside hormone panels and a complete clinical history. The right combination, at the right dose, within the right hormonal context, designed by a clinician who understands all three dimensions.

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PT-141 · Pricing at consultation