Every Brand. The Right One for You.
5
FDA-Approved Brands
6–9
Months: Daxxify®
12
Treatment Areas
15 min
Typical Session
Not All Neuromodulators Work the Same Way.
Botox®, Dysport®, Xeomin®, Jeuveau®, and Daxxify® are all FDA-approved botulinum toxin type A neuromodulators, they relax the muscles that create expression lines. But they differ in molecular formulation, onset speed, spread characteristics, duration, and unit dosing in ways that make some brands better suited to specific areas and patient profiles.
Daxxify® is the most significant advancement in this category in decades.Its peptide stabilizer binds faster to nerve receptors and produces results lasting 6–9 months, most patients need only two treatments per year rather than three or four. It is vegan, contains no human or animal-derived proteins, and has the fastest onset of all five brands.
Arbour Longevity’s selects the right brand for your specific treatment area, anatomy, and lifestyle, something a practice with only one or two brands on the shelf cannot offer. The best outcome comes from matching product to patient, not defaulting to whatever is most familiar.
Botox®: The Standard
Most studied · Predictable · Best for precision areas · 3–4 months
Daxxify®: Longest Lasting
6–9 months · Peptide-based · Vegan · Fastest onset 2 treatments/year
Dysport®: Fastest & Broadest
2–3 day onset · Good for larger areas (forehead) · 3–4 months
Xeomin®: Pure Form
No accessory proteins · Preferred for long-term use · 3–4 months
Jeuveau®: Aesthetics-Only
Designed exclusively for cosmetic use · Fast onset 2–3 days
Five Options. One Clinician Who Knows Each One.
Allergan · Most Popular
Botox®
onabotulinumtoxinA
The gold standard. Decades of safety data.
The most studied, most widely used neuromodulator in the world. Predictable results, controlled spread, and a 20+ year clinical track record. The default choice for precision areas and first-time patients.
Onset
4–7 days
Duration
3–4 months
Visits/year
3–4
Revance · Longest Lasting
Daxxify®
daxibotulinumtoxinA-lanm
6–9 months. The only neuromodulator that lasts this long.
Daxxify® uses a peptide stabilizer that binds faster and holds longer, producing results lasting 6–9 months compared to 3–4 months for other brands. Two treatments per year. Vegan. No human or animal proteins. Daxxify offers among the fastest onset of any FDA-approved neuromodulator, with most patients seeing visible results within 24 to 48 hours.
Onset
1–2 days
Duration
6–9 months
Visits/year
2
Galderma · Fastest Spread
Dysport®
abobotulinumtoxinA
Fast onset. Broader diffusion. Ideal for large areas.
Dysport® diffuses more broadly than Botox®, making it well-suited for the forehead where broader coverage is desirable. Onset as fast as 2–3 days. Note: requires roughly 2.5× the units of Botox® for equivalent effect; compare total area cost, not per-unit price.
Onset
2–3 days
Duration
3–4 months
Visits/year
~2.5× vs Botox®
Merz · Pure Formula
Xeomin®
incobotulinumtoxinA
Stripped of accessory proteins. Preferred for long-term treatment.
Xeomin® is a “naked” neurotoxin, processed to remove accessory proteins while preserving only the active toxin. Some clinicians prefer it for long-term patients where reducing potential antibody development is a consideration. Unit dosing equivalent to Botox®.
Onset
3–5 days
Duration
3–4 months
Visits/year
1:1 vs Botox®
Evolus · Aesthetics-Only
Jeuveau®
prabotulinumtoxinA-xvfs
Designed purely for cosmetic use. Fast onset.
Jeuveau® was developed exclusively for aesthetic use, not repurposed from a medical formulation. Fast 2–3 day onset, unit dosing equivalent to Botox®, and often the most accessible price point for patients maintaining regular treatments. Particularly popular with younger preventive-use patients.
Onset
2–3 days
Duration
3–4 months
Visits/year
1:1 vs Botox®
Note on Dysport®: Dysport® has a different unit conversion ratio, your clinician explains the comparison at your appointment. Your clinician provides a direct comparison at consultation.
Nine Concerns. Each With a Specific Approach.
Glabellar Lines & Frown Lines
The vertical lines between the brows, the “11s,” are the most commonly treated area and the primary FDA-approved indication for all five brands. Creates a more relaxed, approachable expression without looking frozen when done well.
Crow's Feet
The lateral periorbital lines that appear with smiling and squinting, one of the areas where technique matters most. The goal is softening without eliminating the expression entirely. Precise placement preserves natural movement.
Brow Lift
Strategic placement of small amounts laterally at the brow depressors (orbicularis) elevates the brow tail, opening the lateral eye area and producing a subtle lift without surgery. Can be combined with PDO brow threads for a more significant result.
Bunny Lines
The diagonal lines across the nasal bridge that appear with facial expressions, most visible when smiling or scrunching. Often overlooked but significant for patients who want comprehensive upper face smoothing.
Lip Flip
Small doses in the orbicularis oris relax the upper lip muscle, causing it to subtly “flip” outward, creating the appearance of a fuller upper lip without adding volume. An elegant alternative to lip filler for patients seeking subtle definition enhancement.
Chin Dimpling
The “peau d’orange” or cobblestone texture of the chin produced by mentalis muscle hyperactivity responds well to small neuromodulator doses, producing a smoother, more refined chin surface. Often combined with chin filler for comprehensive lower face improvement.
Masseter / Jawline Slimming
Botox® injected into the masseter muscle achieves two outcomes simultaneously, slimming the lower face by reducing masseter hypertrophy, and relieving the jaw tension, headaches, and dental wear associated with bruxism. One of the highest-demand treatments among Arbour Longevity's patients. Results take 4–6 weeks as muscle atrophy develops.
Neck Bands (Platysmal)
Platysmal bands, the vertical cords that appear in the neck with aging and muscle use, respond well to careful neuromodulator placement. The “Nefertiti lift” technique extends treatment to the lower face and jawline simultaneously, producing a subtle neck and jaw lift effect. Often combined with PDO thread neck treatment.
Hyperhidrosis
Excessive sweating of the underarms, palms, or soles is one of the most clinically significant medical applications of neuromodulators. Botox® blocks the nerve signals to sweat glands, producing dramatic reduction in sweating lasting 6–12 months in most patients. A treatment that can provide significant relief for patients with hyperhidrosis..
TMJ / Bruxism
Jaw clenching, teeth grinding, and temporomandibular joint pain driven by masseter and temporalis hyperactivity respond well to neuromodulator treatment. Arbour Longevity’s clinician approaches this as a clinical protocol: assessing jaw anatomy, symptom severity, and the interaction with dental management.
Gummy Smile
Excessive gingival display, where the gum line is visible when smiling, can be dramatically reduced by precise injection of the levator labii superioris alaeque nasi muscle. Small amounts, precise placement, significant aesthetic impact for appropriate candidates.
Downturned Mouth (DAO)
The depressor anguli oris (DAO) pulls the corners of the mouth downward, producing a resting expression that reads as unhappy or disapproving. Relaxing this muscle lifts the mouth corners into a more neutral position, significantly improving resting expression without the frozen look of over-treating larger areas.
Your Arbour Longevity Neuromodulator Session
15 Minutes. Results That Last Months.
Assessment
Preparation
Injection
Results
Post-treatment: Avoid lying down for 4 hours. No vigorous exercise for 24 hours. No facial massage or pressure on treated areas for 24 hours. Mild redness or swelling at injection sites resolves within hours. Touch-up appointments are available at 2 weeks if any area needs adjustment, always at no additional charge for same-session underdosing.
Explore Further
Frequently Asked Questions
What Patients Ask About Neuromodulators at Arbour Longevity .
Botox cost in Ann Arbor depends on three factors: the treatment areas, the brand chosen, and the number of units your anatomy requires.
At Arbour Longevity, Botox is priced at $13/unit. A single targeted area such as the glabella (the 11s) typically requires 20-30 units, with a starting cost of approximately $260 to $390. Larger or combined treatment plans scale accordingly.
Daxxify, which produces results lasting 6 to 9 months compared to 3 to 4 months for Botox, can make the annual investment comparable to or less than shorter-duration brands despite a higher per-session cost. Your clinician confirms exact pricing at your appointment before any treatment begins.
Daxxify (daxibotulinumtoxinA-lanm) is an FDA-approved botulinum toxin type A neuromodulator developed by Revance Therapeutics. It differs from Botox in three significant ways: formulation, duration, and onset.
Formulation: Daxxify uses a peptide-based stabilizer rather than human or animal-derived proteins, making it the only vegan neuromodulator currently approved.
Duration: Daxxify produces results lasting 6 to 9 months, compared to 3 to 4 months for Botox. Most Daxxify patients require only 2 treatments per year.
Onset: Daxxify offers among the fastest onset of any FDA-approved neuromodulator, with most patients seeing visible results within 24 to 48 hours.
Daxxify is dosed differently than Botox. For the glabella, Daxxify uses 40 units versus Botox's 20 units. Despite the higher per-session cost, the longer 6 to 9 month duration often makes the annual investment comparable to or less than shorter-acting brands.
The right neuromodulator brand depends on your treatment area, lifestyle, and aesthetic goals. At Arbour Longevity in Ann Arbor, all five FDA-approved botulinum toxin type A neuromodulators are available, allowing your clinician to match the brand to your specific presentation rather than defaulting to whatever is on the shelf.
Brand selection by primary use case:
• Botox: best for precision areas and patients who prefer the most studied option (3 to 4 month duration)
• Daxxify: best for patients who want maximum duration and fewer appointments (6 to 9 month duration, ideal for busy schedules)
• Dysport: best for the forehead and larger treatment areas where broader diffusion is beneficial (3 to 4 month duration, fast 2 to 3 day onset)
• Xeomin: best for long-term patients who prefer a pure-form product without accessory proteins (3 to 4 month duration)
• Jeuveau: best for cosmetic-only patients seeking an accessible price point (3 to 4 month duration, fast 2 to 3 day onset)
Your Arbour Longevity clinician discusses all five options at consultation and recommends the right brand based on your facial anatomy, treatment goals, and schedule.
Yes. Botox is highly effective for treating TMJ (temporomandibular joint) disorders and bruxism (teeth grinding and jaw clenching), and it is one of the most clinically significant medical applications of neuromodulators.
Botox works by relaxing the masseter muscle, the primary muscle responsible for jaw clenching. As masseter hyperactivity decreases, patients typically experience reduction in jaw pain, fewer tension headaches, and less dental wear from grinding. The treatment also produces a slimming effect on the lower face as the masseter gradually reduces in size.
Treatment protocol at Arbour Longevity:
• Typical dosing: 25 to 50 units per side
• Onset: improvement begins within 1 to 2 weeks• Peak results: 4 to 6 weeks as muscle activity decreases
• Duration: 4 to 6 months per treatment cycle
TMJ and bruxism treatment is approached as a clinical protocol, with assessment of jaw anatomy, symptom severity, and coordination with the patient's dental management.
Botox duration varies by brand and individual factors. The standard duration for Botox (onabotulinumtoxinA) is 3 to 4 months for most patients, with longer-acting alternatives available.
Duration by neuromodulator brand:
• Botox: 3 to 4 months
• Xeomin: 3 to 4 months
• Jeuveau: 3 to 4 months
• Dysport: 3 to 4 months
• Daxxify: 6 to 9 months, the longest duration of any FDA-approved neuromodulator
Individual duration varies based on metabolism, treatment area (high-movement areas like the lips return faster), and unit dosage relative to muscle size. Regular maintenance at appropriate intervals preserves results and may extend duration over time as muscle memory adjusts.
What They Said Two Weeks Later.
★★★★★
"I switched to Daxxify® after years of Botox® and the difference in duration is exactly what was promised. I went from 4 appointments a year to 2. The results look identical, just last twice as long."
★★★★★
"The masseter treatment changed my life. I’d had jaw pain and grinding for years. Six weeks after treatment: no more morning headaches, no more jaw soreness. The jawline slimming was a bonus I didn’t expect to notice as much as I did."
★★★★★
"I appreciate that Arbour Longevity actually explains the difference between the brands rather than just defaulting to whatever. My clinician recommended Jeuveau® for my first treatment and the result was exactly what I wanted, natural, not frozen."
Botox & Neuromodulators · Ann Arbor
Five Brands. One Right Answer for You.
Book your Arbour Longevity neuromodulator appointment. Your clinician assesses your facial anatomy, recommends the right brand and unit count, and delivers the result, natural, precise, and exactly as discussed.
Ann Arbor, Michigan
Regenerative medicine and aesthetic arts: where science meets the artistry of transformation.
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